TG6050
TG6050, an innovative oncolytic virus from the Invir.IO® platform,
armed oncolytic virus given by intravenous administration.
TG6050 has been engineered to express human IL-12, a cytokine that triggers a powerful antitumor immune response, and a full length anti-CTLA4 antibody.
Discover how TG6050 works
A novel immunotherapy
TG6050 is based on a patented viral vector, designed to induce a strong immune response against the tumor. The virus has been optimized to selectively multiply in the tumor, where it will induce an immune response and lead to the production of powerful drugs (IL-12 and anti-CTLA4). The objective: to achieve high concentrations of these drugs only in the tumor, for improved efficacy and fewer side effects than those observed with the systemic administration of these drugs. TG6050 will be administered intravenously, an equally innovative mode of administration for an oncolytic virus. This route of administration makes it possible to target patients with disseminated disease with numerous metastases visible and invisible by medical imaging techniques.

Clinical trial
Indication | Phase | |
---|---|---|
Non-small cell lung cancer – IV | Phase I (Delivir Trial) |
- August 27, 2024 - Transgene — Preclinical Proof of Concept Data of Oncolytic Virus TG6050 published in JITC
- May 10, 2023 - Transgene – First Patient Dosed in Phase I Trial Evaluating TG6050, a Novel IL-12-Armed Oncolytic Virus Administrated Intravenously, in Non-Small Cell Lung Cancer
- April 17, 2023 - Transgene – Preclinical Results Showing TG6050, a Novel Oncolytic Virus, induces Tumor Regression by Activating Innate and Adaptive immune responses presented at AACR
>> All press releases
- TG7010: a Novel Chimeric Oncolytic Poxvirus Encoding IL-12 with Improved Properties for Systemic Delivery
J. Foloppe, et al.
IOVC 2024
Abstract available on the IOVC website – Download the abstract and the poster - TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody, favors tumor regression via profound immune remodeling of the tumor microenvionment
L.Fend, et al.
ESMO 2024
Abstract available on the CICON website – Download the abstract and the poster - TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody, favors tumor regression via profound immune remodeling of the tumor microenvionment
F. Azar et al.
Journal for ImmunoTherapy of Cancer, July 2024
Download the publication here
Publication